![]() ![]() ![]() 5 Longbin Road, Development Zone, Dalian, 116011, People’s Republic of China, Tel +86-18098876419, Fax +85963, Email Facet joint osteoarthritis (OA) is the most frequent form of facet joint syndrome. Ruihuan Du,1 Gang Xu,1,2 Xujue Bai,1 Zhonghai Li1,2 1Department of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian, People’s Republic of China 2Key Laboratory of Molecular Mechanism for Repair and Remodeling of Orthopedic Diseases, Dalian, People’s Republic of ChinaCorrespondence: Zhonghai Li, The Third Department of the First Affiliated Hospital of Dalian Medical University, No. During the 12 months of follow-up only 3 patients had a relapse of the cyst (at 6 months) that were retreated with a 100% success.ĬT-guided ozone therapy for symptomatic LFSC is a safe and innovative treatment option, with good clinical results at 12 months follow-up in a significative percentage of patients, thus reducing the need for invasive surgical interventions. ![]() At 1 month evaluation, 92% of the patients referred partial or complete symptomatic response 86% of patients at 3 months and 84% at 6 months confirmed symptoms improvement final assessment, at 12 months after intervention, outlined overall significant clinical improvement in 81% of patients. Ozone administration was technically successful in 100% of procedures no immediate complications occurred. Follow-up MRI imaging at 6 and 12 months were obtained and confronted with the pre-procedural MRI to analyse cyst modification after the intervention. Clinical outcome was assessed with Numerical Rating Scale (NRS) and Oswestry Disability Index (ODI) evaluations, obtained prior to the intervention and at 1-, 3-, 6- and 12-months follow-up. We retrospectively reviewed clinical records and imaging studies of 77 patients who underwent CT-guided ozone treatment of symptomatic facet joint synovial cysts in our department over a 5-year span. To evaluate the clinical and radiological outcomes, in terms of safety and efficacy, of a new treatment method for symptomatic lumbar facet synovial cysts (LFSC), based on ozone injection inside the cyst. ![]()
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Seduce other characters to gain political power and call in favors with the allure of your influence. Protect your kingdom from devious plots and brew some of your own in other domains by utilizing your spymaster and his agents.Bolster your forces by researching new technologies that will bring in war funds and new equipment. Build up your military might by recruiting men-at-arms and formidable knights to your ranks.Beware of going against your chosen nature, though, as doing so might bring dire consequences. Choose from different lifestyles that will have you leaning towards specific traits. ![]() ![]() * The indirect economic costs reported by RAND are higher than costs reported in other literature. This equates to an estimated loss in annual GDP of approximately $170.7 billion for the 12 European countries analyzed, $19.6 billion for Canada and $207.5 billion for the United States. In terms of indirect costs, chronic insomnia disorder was associated with approximately 11 to 18 days of absenteeism, 39 to 45 days of presenteeism (defined as reduced productivity while at work), and 44 to 54 days of overall productivity loss annually. It's important that we acknowledge chronic insomnia as a legitimate medical condition and recognize the enormous burden it places on individuals and society as a whole.”Īccording to the recently published figures, the cost of chronic insomnia disorder is substantial. Despite sleep being a biological necessity to ensure optimal functioning throughout the day, 5 millions of people globally are not getting restorative sleep due to chronic insomnia disorder. Their findings are unique by revealing, for the first time, the indirect economic and ‘hidden’ wellbeing costs of chronic insomnia disorder. An example of our commitment to furthering this understanding is our sponsorship of the research published by RAND Europe. “Our scientists have over 20 years of experience in the field of sleep research, through the orexin system, and continue to work on better understanding of the science of sleep and chronic insomnia disorder. Jean-Paul Clozel, MD and Chief Executive Officer of Idorsia, commented: Conducting more research on the prevalence of CID and its societal and economic impacts.Addressing physician knowledge gaps and improving the identification and management of insomnia.Incorporating insomnia screening during routine clinical visits.1,2 The report also provided additional insights on chronic insomnia disorder.Īs part of the company’s ongoing commitment to advance research in insomnia, Idorsia supports RAND Europe’s recommendation and highlights the importance of: * 1 The intangible annual wellbeing losses range from $1.5 billion and $127.1 billion (for a total of $239.5 billion) in the countries of focus, which include France, Italy, Germany, Spain, the United Kingdom, the United States, and Canada. RAND Europe’s findings indicate the indirect economic costs associated with lost work productivity ranging between $1.8 billion and $207.5 billion (for a total of $417 billion) in gross domestic product (GDP) across the countries RAND analyzed. ![]() ![]() The new report focuses on both the indirect economic costs (i.e., non-healthcare related costs) and the “hidden” intangible costs (i.e., costs that are not directly observed through economic transactions but nonetheless have impacts on an individual’s health or well-being) associated with chronic insomnia disorder. Idorsia commissioned RAND Europe, an independent, not-for-profit policy research organization, to help fill some of the knowledge gaps associated with understanding the financial burden of chronic insomnia disorder and to deliver new peer-reviewed research into the impacts of insomnia. ![]() On World Sleep Day, Idorsia Ltd (SIX: IDIA) highlights the publication of a first-of-its-kind report by RAND Europe on the economic and societal impact of chronic insomnia disorder, † “ The Societal and Economic Burden of Insomnia in Adults: An International Study”. Idorsia partners with the World Sleep Society on educational and disease awareness activities focused on the theme: Sleep is Essential for Health.Reducing the impact of CID could result in a boost to the GDP of national economies ranging from 0.64% to 1.31% across the countries of focus * 1.New report indicates annual lost productivity costs of $417 billion in GDP across working age populations in the countries of focus * and annual “hidden” intangible wellbeing losses of $239.5 billion 1.Chronic insomnia disorder (CID) is a persistent medical condition that prevents sufferers from getting restorative sleep 1-3 research on wider societal and indirect economic costs associated with CID have been limited to date 1. ![]() ![]() The game can be controlled by the joystick in port 2. Selective sound effects can be heard when collecting treasures, creating traps in the walls, while falling, when all treasures have been collected and the level can be exited and when you lose a life. There is no background music, which adds to the calm atmosphere. Your man and the guards are the only animated parts in every screen, so the atmosphere is calm. blue or green is used), white ladders and poles and mint coloured guards. Every screen consists of a black background, red stones and walls (in gamesets of other parties different colours as e.g. The game shows a typical side platform view on one screen. Level5 disk version, Level2 tape/cartridge version You can copy or move whole levels, and the professional version even allows you to create levels with automatic gamesets. press the joystick right and up and your man will walk to the right until it reaches a ladder and will then head up without any additional joystick movement.Īnother feature is the game editor, with which you can format an empty disk with the Lode Runner format and save up to 150 self-made levels. The game engine is astonishingly fluent, so you can e.g. There is no time limit but the guards which reappear after their death keep you busy. No matter how far you will fall, you cannot get hurt. You cannot jump, but you carry a weapon with you, with which you can dissolve the bricks for a certain time. When you have finished all 150 levels, the game starts again with raised speed. If you have reached the uppermost line of the screen, you will get into the next level. As soon as you have collected all the boxes, a melody rings and up until now invisible ladders can appear. You can run, use the ladders, climb along the bars and collect treasures. ![]() Up to 5 enemies try to make it hard for you. ![]() ![]() Lode Runner is an outstanding platform game, where gold treasures need to be collected in 150 levels. ![]() ![]() ![]() ![]() In short, genre cultists are pretty much the exclusive audience here. ![]() Director Anthony Hickox helmed both offerings, without quite deciding how much humor was too much humor. But why no parody of Vincent Price in House of Wax? It goes on too long, but there are weird celebrity guest stars aplenty (Bruce Campbell, David Carradine, Martin Kemp). The sequel is livelier, with Galligan now passing through a time portal that transports him to various classic film scenarios: Frankenstein, Dawn of the Dead, Alien, and, briefly and amusingly, Nosferatu (that's Drew Barrymore as one of the virgins cowering in bed). In Waxwork, Zach Galligan and his teen friends investigate a wax museum, where they are menaced by the re-animated tableaux. The main draw of these low-budget horror pictures is their unabashed affection for the great horror movies of the past. In Waxwork II: Lost in Time, Mark and Sarah, who survived the killer wax museum, must travel to another dimension to combat the still-present evil figure. Waxwork II: Lost in Time Director: Anthony Hickox Release: 1992 March, 1 Country: USA Runtime: 104 minutes Genre: Comedy / Fantasy / Horror / Sci-Fi. However, Mark's involvement in these other worlds may not be an accident. To find the proof that will clear her, the pair travel through time and space to dimensions full of historical, movie, and book characters. Mark and Sarah survived the mayhem from the first movie only to have Sarah on trial for a murder committed by a dismembered hand. They grab the time machine compass thingy and go back in time to look for evidence that the girl is telling the truth, and get embroiled in different conflicts along the way. She and her boyfriend go to Sir Wilfred's house for clues, where they find a film he has prepared for them, pointing the way to his secret evil-thing-fighting stash. The couple that survives the wax museum in "Waxwork" is followed by a dismembered hand, which kills the girl's father, for which she must stand trial (those lawyer types are shrewd, they weren't going for that dismembered-hand stuff). Zach Galligan (Mark Loftmore) Monika Schnarre (Sarah Brightman) Martin Kemp (Baron Von Frankenstein) Bruce Campbell (John Loftmore) Michael Des Barres (George) Jim Metzler (Roger) Sophie Ward (Elenore) Marina Sirtis (Gloria) Billy Kane (Nigel) Joe Baker (The Peasant) Juliet Mills (The Defense Lawyer) John Ireland (King Arthur) Patrick Macnee (Sir Wilfred) David Carradine (The Beggar) Alexander Godunov (Scarabis) Bach's Life & Documentaries: Index by Titleīach's Music in Soundtracks: Index by Title ![]() ![]() ![]() SelfPrivacy - Self-Hosted Privacy Based Services. ![]() Exodify - Display Tracker Count on Apps in Play Store.FOSS Smartphone Hardening, 2 - Non-Root Smart Phone Hardening Guide.Guardian Project / 2, Divestos Apps or InviZible - Privacy Based Apps / Tools.Gear VPN, Adguard VPN, GoatVPN, Vpnify, YourFreedomVPN, GoFLy, TempoVPN, VPN Door, VPNhub or Clash / Profiles - Free VPNs.⭐ Aegis, Authy, AuthenticatorPro, Mauth or andOTP - Two-Factor Authentication.⭐ DPITunnel, PowerTunnel or Xandroid - Proxies. ![]()
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You can find these lost CCC camps near the Smokemont area. When you visit the camps today, you will see an old chimney, fire hydrant, drinking fountain and other historical pieces. This helped create jobs during the Great Depression and helped restore the forestry for the new national park. When the Smokies were becoming a national park, Franklin Roosevelt formed the Civilian Conservation Corps. In the last few years, this entrance has become a little less “secret,” but it’s still not as popular as the Gatlinburg entrance, so it’s still a great place to skip some of the crowds during the peak season. Have you heard of the “secret entrance” to the national park? The Wears Valley entrances is a secret spot, typically where many locals will go to get into the national park. Secret Entrance to the Great Smoky Mountains National Park There are many pull offs, so if you have small children, this is a great drive for stopping and getting out to splash around in the creek and enjoy the views. There’s hiking, picnic areas and, since the road runs beside a stream, there’s lots of water features along the way. This road is away from the crowds and gives you a beautiful experience in the mountains. To reach Upper Tremont Road, you drive through Townsend and into the Great Smoky Mountains National Park, then you turn right toward Cades Cove and you’ll turn left at the sign for Great Smoky Mountains Institute at Tremont.Įven though Upper Tremont isn’t directly in Cades Cove, it’s very close to Cades Cove, so you get to experience the same type of mountain beauty that you’ll find in the Cove. If you’ve ever driven along Upper Tremont Road, you’ve probably been impressed by this hidden beauty in the park. Gourley’s Pond is one of our favorite hidden gems in the Smoky Mountains, but it is a wet-weather pond, so if there’s not been any rainfall, it may be empty. Walk down the loop road about 200 feet until you see a path on your right, then continue along that trail for about 100 feet until you see the pond. You can’t see the pond from the road, so you’ll need to leave your car at LeQuire Cemetery at the end of Sparks Lane. The Gourley Pond is one of the most overlooked areas in Cades Cove. Make sure you see these on your next vacation! So, we’re sharing some of our favorite secret places in Cades Cove and around the Great Smoky Mountains National Park. ![]() After reading a recent article about a secret underground city discovered beneath Cades Cove, we started wondering what it would be like if there really were secret places in the Smokies. ![]() ![]() ![]() It can cost you 15 years in jail, targeting also international journalists who are doing their vital work in Russia. The Kremlin has introduced a law criminalising what they call “fake” information about the war in Ukraine. The Russian leadership is cracking down on independent media, on civil society, has banned Twitter, has banned Facebook and a number of foreign media to be able to operate in Russia. And they are an integral part of the aggression - it not just bombing houses, infrastructure, the bodies of the people they are bombing their minds, they are bombing their spirits. The state media and “the ecosystem” around them are being used as instruments to push these narratives, to manipulate and to mislead. And if he wants, he can solve it by just stopping the war. ![]() Let me say once again, our measures are against the Russian leadership, not against the Russian people, and the current situation is a result of President Putin’s actions. Also, the alleged “Russo-phobia” that the state-affiliated media report on is another thing that people in Russia listen to. Systematically, these kind of news are being spread. They claim systematically that the Ukrainian authorities are bombing their own citizens or provoking nuclear incidents in order to blame Russia. The Kremlin and its outlets are systematically lying about the situation, about the military situation and about the suffering of the Ukrainian population. Well, history can be interpreted in very different ways, but to consider that Zelensky is a war criminal and Nazi who is committing genocide against the Russian people is not a matter of historial interpretation. Undermining the legitimacy of the democratically elected Ukrainian Government, presenting them as the result of a “coup d’Etat”, who came to power not through elections but through a “coup d’Etat”: “he is a criminal, a war criminal, he is a Nazi, he is a dictator”. This is the kind of things that they are systematically spreading. Zelensky is a criminal, is a puppet in the hands of the Western people, and when they come to Kyiv, they will do a second Nuremberg, in order to clean Ukraine of the Nazis who are committing genocide against Russian people”. Over the last weeks, much before the invasion started, the Kremlin’s outlets were preparing the ground, by reversing the cause and consequences of this aggression and portraying Russia and the Russian people as a kind of victim: “Genocide” “ Zelensky is committing genocide. Information manipulation and interferences is something that the Russian propaganda machine is actively using to accompany Russia’s military campaign in Ukraine, spreading false information among their own population about why this invasion has taken place and what is the situation in Ukraine. So, I therefore very much welcome your report and the work of the Special Committee on Foreign Interference. This poses a clear threat to our democracy, to our stability, to our security – and we need to address it. We are witnessing how Russia’s assault on Ukraine continues, and this assault painfully highlights why we need to pay more attention to foreign interference, and in particular to foreign disinformation and information manipulation. ![]() Good morning, dear Mr Chairman, dear Members of the Committee, dear Members of the European Parliament attending this debate, ![]() |
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